Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

TIMD4 Protein (AA 25-315) (Fc Tag)

TIMD4 Spezies: Human Wirt: HEK-293 Cells Recombinant >98 % (SDS-PAGE)
Produktnummer ABIN6253411
  • Target Alle TIMD4 Proteine anzeigen
    TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 25-315
    Spezies
    • 7
    • 6
    • 1
    Human
    Quelle
    • 5
    • 4
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses TIMD4 Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    Tim-4 (human):Fc (mouse) (rec.)
    Spezifität
    The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of mouse IgG2a.
    Produktmerkmale
    Protein. The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell, immunoglobulin, Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
    Reinheit
    >98 % (SDS-PAGE)
    Endotoxin-Niveau
    <5EU/mg protein (LAL test, Lonza).
    Biological Activity Comment
    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
    Top Product
    Discover our top product TIMD4 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Konzentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in PBS.
    Handhabung
    Avoid freeze/thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • Target
    TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
    Andere Bezeichnung
    Tim-4 (TIMD4 Produkte)
    Synonyme
    RGD1564516 Protein, MGC99322 Protein, TIMD4 Protein, B430010N18Rik Protein, TIM-4 Protein, Tim4 Protein, SMUCKLER Protein, TIM4 Protein, T-cell immunoglobulin and mucin domain containing 4 Protein, T-cell immunoglobulin and mucin domain containing 4 L homeolog Protein, T cell immunoglobulin and mucin domain containing 4 Protein, Timd4 Protein, TIMD4 Protein, timd4.L Protein
    Hintergrund

    Alternate Names/Synonyms: TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4

    Product Description: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell, immunoglobulin, Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.

    Molekulargewicht
    ~80kDa (SDS-PAGE)
    NCBI Accession
    NP_612388
    Pathways
    Cancer Immune Checkpoints
Sie sind hier:
Kundenservice