Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

LTBR Protein (AA 31-225) (Fc Tag)

LTBR Spezies: Human Wirt: CHO Cells Recombinant >98 % (SDS-PAGE)
Produktnummer ABIN6253335
  • Target Alle LTBR Proteine anzeigen
    LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 31-225
    Spezies
    • 14
    • 7
    • 2
    Human
    Quelle
    • 8
    • 6
    • 6
    • 2
    • 1
    CHO Cells
    Aufreinigungstag / Konjugat
    Dieses LTBR Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    LTbetaR (human):Fc (human) (rec.) (non-lytic)
    Spezifität
    The extracellular domain of human LTbetaR (aa 31-225) is fused to the N-terminus of the Fc region of a mutant human IgG1.
    Produktmerkmale
    Protein. The extracellular domain of human LTbetaR (aa 31-225) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
    Reinheit
    >98 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.06EU/μg protein (LAL test, Lonza).
    Biological Activity Comment
    Shows the biological function of the LTbetaR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
    Top Product
    Discover our top product LTBR Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Konzentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in PBS.
    Handhabung
    Avoid freeze/thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • Target
    LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))
    Andere Bezeichnung
    LTbetaR (LTBR Produkte)
    Synonyme
    AI256028 Protein, CD18 Protein, LTbetaR Protein, Ltar Protein, TNF-R-III Protein, TNFCR Protein, TNFR-RP Protein, TNFR2-RP Protein, TNFRrp Protein, Tnfbr Protein, Tnfrsf3 Protein, D12S370 Protein, LT-BETA-R Protein, TNFR3 Protein, TNFRSF3 Protein, lymphotoxin beta receptor Protein, lymphotoxin B receptor Protein, Ltbr Protein, LTBR Protein
    Hintergrund

    Alternate Names/Synonyms: Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3

    Product Description: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

    NCBI Accession
    NP_002333
    Pathways
    NF-kappaB Signalweg
Sie sind hier:
Kundenservice