CCL20 Protein

Produktnummer ABIN621130

Produktdetails

Target: CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

Protein-Typ: Recombinant

Spezies: Human

Wirt: Bitte anfragen

Sequenz: ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM .

Produktmerkmale: Recombinant Human Macrophage Inflammatory Protein-3 alpha (MIP-3a) / CCL20

Reinheit: > 97.0 % as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.It is recommended to reconstitute the lyophilized MIP-3 Alpha in sterile 18M omega cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lagerung: -20 °C

Referenzen

Nicholson, Mavrangelos, Bird, Bresatz-Atkins, Eastaff-Leung, Grose, Gundsambuu, Hill, Millard, Sadlon, To, Zola, Barry, Krumbiegel: "PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20." in: Cellular immunology, Vol. 275, Issue 1-2, pp. 12-8, (2012) (PubMed).

Galli, Basilico, Cortese, Di Giusto: "[Spontaneous hematoma of the abdominal wall. Review of a clinical case load]." in: Minerva chirurgica, Vol. 44, Issue 21, pp. 2255-8, (1990) (PubMed).

Antigendetails

Target: CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

Andere Bezeichnung: Macrophage Inflammatory Protein-3 alpha (MIP-3a) / CCL20 (CCL20 Produkte)

Synonyme: MIP-3ALPHA Protein, CCL20 Protein, si:dkey-150o13.1 Protein, CKb4 Protein, LARC Protein, MIP-3-alpha Protein, MIP-3a Protein, MIP3A Protein, SCYA20 Protein, ST38 Protein, MIP-3A Protein, MIP-3[a] Protein, Scya20 Protein, exodus-1 Protein, C-C motif chemokine ligand 20 Protein, chemokine (C-C motif) ligand 20b Protein, chemokine (C-C motif) ligand 20 Protein, CCL20 Protein, ccl20b Protein, Ccl20 Protein

Hintergrund: MIP-3 Alpha Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 8 kDa. The MIP-3a is purified by proprietary chromatographic techniques. Introduction: CCL-20 is a chemotactic factor that draws lymphocytes and neutrophils, rathar than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL-20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL-20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL-20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria. MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission. Synonyms: S Small inducible cytokine A20 precursor, CCL20, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Liver and activation- regulated chemokine, CC chemokine LARC, Beta chemokine exodus-1, CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20.

Pathways: Phosphorylierungen bei SARS-CoV-2 Infektion