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CCL17 Protein

CCL17 Spezies: Human Recombinant > 97.0 % as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Produktnummer ABIN620943
  • Target Alle CCL17 Proteine anzeigen
    CCL17 (Chemokine (C-C Motif) Ligand 17 (CCL17))
    Protein-Typ
    Recombinant
    Spezies
    • 11
    • 5
    • 4
    • 2
    • 1
    • 1
    Human
    Wirt
    Bitte anfragen
    Sequenz
    ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER S.
    Produktmerkmale
    Recombinant Human Thymus and Activation Regulated Chemokine (TARC) / CCL17
    Reinheit
    > 97.0 % as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
    Top Product
    Discover our top product CCL17 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    The protein was lyophilized from a concentrated (0.5mg/ml) solution containing 20mM PBS and 150mM NaCl pH-7.4.It is recommended to reconstitute the lyophilized CCL17 in sterile 18M omega cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
    Lagerung
    -20 °C
  • García, Cidoncha, Bote, Hinchado, Ortega: "Altered profile of chemokines in fibromyalgia patients." in: Annals of clinical biochemistry, Vol. 51, Issue Pt 5, pp. 576-81, (2014) (PubMed).

  • Target
    CCL17 (Chemokine (C-C Motif) Ligand 17 (CCL17))
    Andere Bezeichnung
    Thymus and Activation Regulated Chemokine (TARC) / CCL17 (CCL17 Produkte)
    Synonyme
    A-152E5.3 Protein, ABCD-2 Protein, SCYA17 Protein, TARC Protein, CCL17 Protein, Abcd-2 Protein, Scya17 Protein, Scya17l Protein, Tarc Protein, abcd2 Protein, C-C motif chemokine ligand 17 Protein, chemokine (C-C motif) ligand 17 Protein, ATP-binding cassette sub-family D member 2 Protein, CCL17 Protein, Ccl17 Protein, LOC100537809 Protein
    Hintergrund
    CCL17 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 8 kDa. The TARC is purified by proprietary chromatographic techniques. Introduction: TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1alpha, MIP-1beta, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. Synonyms: C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273.
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