MICA Protein (AA 24-297) (His tag)

Produktnummer ABIN7280944

Produktdetails

Target: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-297

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MICA Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MEPHSLRYNL TVLSWDGSVQ SGFLTEVHLD GQPFLRCDRQ KCRAKPQGQW AEDVLGNKTW DRETRDLTGN GKDLRMTLAH IKDQKEGLHS LQEIRVCEIH EDNSTRSSQH FYYDGELFLS QNLETEEWTM PQSSRAQTLA MNVRNFLKED AMKTKTHYHA MHADCLQELR RYLKSGVVLR RTVPPMVNVT RSEASEGNIT VTCRASGFYP WNITLSWRQD GVSLSHDTQQ WGDVLPDGNG TYQTWVATRI CQGEEQRFTC YMEHSGNHST HPVPSLEHHH HHH

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: Liquid, In Phosphate buffered saline (  pH 7.4) containing 10 % glycerol, 1  mM DTT

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Andere Bezeichnung: MICA (MICA Produkte)

Synonyme: MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein

Hintergrund: MICA also known as MHC class I polypeptide-related sequence A. This Protein's Function seems to have no role in antigen presentation. It acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. It binding to KLRK1 leads to cell lysis. Recombinant human MICA, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 32.7kDa (283aa) confirmed by MALDI-TOF

Pathways: Activation of Innate immune Response, Transition Metal Ion Homeostasis