zgc:110272 Protein, mp:zf637-1-000774 Protein, BCCIP Protein, DKFZp459K2416 Protein, MGC82792 Protein, tok-1 Protein, MGC89311 Protein, TOK-1 Protein, TOK1 Protein, 1110013J05Rik Protein, BRCA2 and CDKN1A interacting protein Protein, BRCA2 and CDKN1A interacting protein L homeolog Protein, BCCIP Protein, bccip Protein, bccip.L Protein, Bccip Protein
Hintergrund
BCCIP was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Recombinant human BCCIP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Molekulargewicht
38.6kDa(339aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)