ARPP19 Protein (AA 1-112) (His tag)

Produktnummer ABIN5853398

Produktdetails

Target: ARPP19 (cAMP-Regulated Phosphoprotein, 19kDa (ARPP19))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-112

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ARPP19 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSMSAEVPE AASAEEQKEM EDKVTSPEKA EEAKLKARYP HLGQKPGGSD FLRKRLQKGQ KYFDSGDYNM AKAKMKNKQL PTAAPDKTEV TGDHIPTPQD LPQRKPSLVA SKLAG

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: ARPP19 (cAMP-Regulated Phosphoprotein, 19kDa (ARPP19))

Andere Bezeichnung: ARPP19 (ARPP19 Produkte)

Synonyme: ARPP-16 Protein, ARPP-19 Protein, ARPP16 Protein, ENSAL Protein, ARPP-19-A Protein, arpp-16 Protein, arpp-19 Protein, arpp16 Protein, arpp19-a Protein, ensal Protein, 19kDa Protein, 2700024H10Rik Protein, AW559096 Protein, Arpp12 Protein, Arpp19 Protein, Arpp-19 Protein, cAMP regulated phosphoprotein 19 Protein, cAMP regulated phosphoprotein 19kDa L homeolog Protein, cAMP-regulated phosphoprotein 19 Protein, ARPP19 Protein, arpp19.L Protein, Arpp19 Protein

Hintergrund: CAMP-regulated phosphoprotein 19, also known as ARPP19, is protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. This protein may indirectly enhance GAP-43 expression. Recombinant human ARPP19 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 14.7kDa (135aa) confirmed by MALDI-TOF

NCBI Accession: NP_006619

UniProt: P56211

Pathways: Regulation of Carbohydrate Metabolic Process