OBFC2A Protein (AA 1-204) (His tag)

Produktnummer ABIN5853273

Produktdetails

Target: OBFC2A (Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-204

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses OBFC2A Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKV ADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNP DYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.2M NaCl, 50 % glycerol, 2  mM DTT

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: OBFC2A (Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A))

Andere Bezeichnung: NABP1 (OBFC2A Produkte)

Synonyme: OBFC2A Protein, SOSS-B2 Protein, SSB2 Protein, 4930434H03Rik Protein, 4930442A21Rik Protein, 4930488J04Rik Protein, 4933440J18Rik Protein, 5830411E10Rik Protein, AI852561 Protein, Nbp1 Protein, Obfc2a Protein, Ssb2 Protein, RGD1306658 Protein, nucleic acid binding protein 1 Protein, NABP1 Protein, Nabp1 Protein

Hintergrund: Nucleic acid binding protein 1, also known as NABP1, is component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, the protein acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. This protein is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Recombinant human NABP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 24.8 kDa (227aa) confirmed by MALDI-TOF

NCBI Accession: NP_001026886

UniProt: Q96AH0