CHCHD4 Protein (AA 1-142, full length) (His-SUMO Tag)

Produktnummer ABIN5711676

Produktdetails

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Protein-Typ: Recombinant

Proteineigenschaft: full length, AA 1-142

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CHCHD4 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MSYCRQEGKD RIIFVTKEDH ETPSSAELVA DDPNDPYEEH GLILPNGNIN WNCPCLGGMA SGPCGEQFKS AFSCFHYSTE EIKGSDCVDQ FRAMQECMQK YPDLYPQEDE DEEEEREKKP AEQAEETAPI EATATKEEEG SS

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Andere Bezeichnung: MIA40 (CHCHD4 Produkte)

Synonyme: 2410012P20Rik Protein, 2810014D17Rik Protein, AI838740 Protein, MIA40 Protein, TIMM40 Protein, mia40 Protein, timm40 Protein, chchd4 Protein, chchd4a Protein, fc10g04 Protein, wu:fc10g04 Protein, zgc:100849 Protein, si:dkey-202e22.1 Protein, chchd4b Protein, CaO19.2977 Protein, coiled-coil-helix-coiled-coil-helix domain containing 4 Protein, coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog Protein, coiled-coil-helix-coiled-coil-helix domain containing 4a Protein, coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog Protein, Mia40p Protein, Chchd4 Protein, CHCHD4 Protein, chchd4 Protein, chchd4.L Protein, chchd4a Protein, chchd4.S Protein, LOC100361898 Protein, MIA40 Protein

Hintergrund: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermbrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay syst.

Molekulargewicht: 32 kDa

UniProt: Q8N4Q1