TEAD4 Protein (AA 74-434, partial) (His-SUMO Tag)
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- Target Alle TEAD4 Proteine anzeigen
- TEAD4 (TEA Domain Family Member 4 (TEAD4))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 74-434, partial
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses TEAD4 Protein ist gelabelt mit His-SUMO Tag.
- Applikation
- SDS-PAGE (SDS)
- Sequenz
- MYGRNELIAR YIKLRTGKTR TRKQVSSHIQ VLARRKAREI QAKLKDQAAK DKALQSMAAM SSAQIISATA FHSSMALARG PGRPAVSGFW QGALPGQAGT SHDVKPFSQQ TYAVQPPLPL PGFESPAGPA PSPSAPPAPP WQGRSVASSK LWMLEFSAFL EQQQDPDTYN KHLFVHIGQS SPSYSDPYLE AVDIRQIYDK FPEKKGGLKD LFERGPSNAF FLVKFWADLN TNIEDEGSSF YGVSSQYESP ENMIITCSTK VCSFGKQVVE KVETEYARYE NGHYSYRIHR SPLCEYMINF IHKLKHLPEK YMMNSVLENF TILQVVTNRD TQETLLCIAY VFEVSASEHG AQHHIYRLVK E
- Aufreinigung
- SDS-PAGE
- Reinheit
- > 90 %
- Top Product
- Discover our top product TEAD4 Protein
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Lagerung
- -80 °C,4 °C,-20 °C
- Informationen zur Lagerung
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- TEAD4 (TEA Domain Family Member 4 (TEAD4))
- Andere Bezeichnung
- TEAD4 (TEAD4 Produkte)
- Synonyme
- TEAD4 Protein, rtef1 Protein, tef-3 Protein, eftr-2 Protein, tefr-1 Protein, tcf13l1 Protein, hrtef-1b Protein, xdtef-1 Protein, xlDTEF-1 Protein, RTEF-1 Protein, TEF-1 Protein, TEF-3 Protein, EFTR-2 Protein, RTEF1 Protein, TCF13L1 Protein, TEF3 Protein, TEFR-1 Protein, hRTEF-1B Protein, ETFR-2 Protein, Etfr2 Protein, FR-19 Protein, TEAD-4 Protein, Tcf13r1 Protein, Tef3 Protein, Tefr Protein, Tefr1 Protein, Tefr1a Protein, TEA domain transcription factor 4 Protein, TEA domain transcription factor 4 S homeolog Protein, TEA domain family member 4 Protein, TEAD4 Protein, tead4 Protein, tead4.S Protein, Tead4 Protein
- Hintergrund
- Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (T) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
- Molekulargewicht
- 56.6 kDa
- UniProt
- Q15561
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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