BCL2L1 Protein (AA 1-209, partial) (His-SUMO Tag)

Produktnummer ABIN5709127

Produktdetails

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-209, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses BCL2L1 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA AESRKGQER

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: B2CL1 (BCL2L1 Produkte)

Synonyme: BCL-XL/S Protein, BCL2L Protein, BCLX Protein, BCLXL Protein, BCLXS Protein, Bcl-X Protein, PPP1R52 Protein, bcl-xL Protein, bcl-xS Protein, Bcl(X)L Protein, Bcl-XL Protein, Bcl-Xs Protein, Bcl2l Protein, BclX Protein, bcl-x Protein, Bcl-xl Protein, Bclx Protein, bcl-X Protein, Bcl-xL Protein, BCL-XL Protein, BCL2L1 Protein, bcl-XL Protein, bcl-x(l) Protein, bcl-xl/s Protein, bcl-xs Protein, bcl2l Protein, bclx Protein, bclxl Protein, xR11 Protein, bcl-xl Protein, blp1 Protein, cb1021 Protein, zfBLP1 Protein, BCL2 like 1 Protein, BCL2-like 1 Protein, Bcl2-like 1 Protein, BCL2-like 1 L homeolog Protein, bcl2-like 1 Protein, BCL2L1 Protein, Bcl2l1 Protein, bcl2l1 Protein, bcl2l1.L Protein

Hintergrund: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial mbrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial mbrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis.

Molekulargewicht: 39.4 kDa

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling