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AP2M1 Protein (AA 1-435, full length) (His-SUMO Tag)

AP2M1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5709053
$501.60
Zzgl. Versandkosten $45.00
Lieferung in 11 Werktagen
  • Target Alle AP2M1 Proteine anzeigen
    AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    full length, AA 1-435
    Spezies
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 9
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses AP2M1 Protein ist gelabelt mit His-SUMO Tag.
    Applikation
    SDS-PAGE (SDS)
    Sequenz
    MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMA AYFGKISEEN IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QHQTKEEQSQ ITSQVTGQIG WRREGIKYRR NELFLDVLES VNLLMSPQGQ VLSAHVSGRV VMKSYLSGMP ECKFGMNDKI VIEKQGKGTA DETSKSGKQS IAIDDCTFHQ CVRLSKFDSE RSISFIPPDG EFELMRYRTT KDIILPFRVI PLVREVGRTK LEVKVVIKSN FKPSLLAQKI EVRIPTPLNT SGVQVICMKG KAKYKASENA IVWKIKRMAG MKESQISAEI ELLPTNDKKK WARPPISMNF EVPFAPSGLK VRYLKVFEPK LNYSDHDVIK WVRYIGRSGI YETRC
    Aufreinigung
    SDS-PAGE
    Reinheit
    > 90 %
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Lagerung
    -80 °C,4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))
    Andere Bezeichnung
    AP2M1 (AP2M1 Produkte)
    Synonyme
    AP50 Protein, CLAPM1 Protein, mu2 Protein, Ap50 Protein, Clapm1 Protein, cb34 Protein, Ap2m1 Protein, dpy-23 Protein, sb:cb34 Protein, zgc:55711 Protein, zgc:85653 Protein, wu:fa97a10 Protein, ap2m1-a Protein, ap2m1 Protein, zgc:56643 Protein, AP2M1 Protein, adaptor related protein complex 2 mu 1 subunit Protein, adaptor-related protein complex 2, mu 1 subunit Protein, adaptor-related protein complex 2, mu 1 subunit, a Protein, adaptor related protein complex 2 mu 1 subunit L homeolog Protein, adaptor-related protein complex 2, mu 1 subunit, b Protein, AP-2 complex subunit mu-1 Protein, clathrin coat assembly protein AP50 Protein, clathrin coat assembly protein ap50 Protein, AP2M1 Protein, Ap2m1 Protein, ap2m1a Protein, ap2m1.L Protein, ap2m1b Protein, ap2m1 Protein, cgd8_950 Protein, PY06523 Protein, PVX_118455 Protein, PVX_123590 Protein, CpipJ_CPIJ003697 Protein
    Hintergrund
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different mbrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to mbrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of mbranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the mbrane proteins involved in receptor-mediated endocytosis. AP-2 ses to play a role in the recycling of synaptic vesicle mbranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmbrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmbrane cargo proteins, it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in mbrane-associated AP-2. The mbrane-specific phosphorylation event appears to involve assbled clathrin which activates the AP-2 mu kinase AAK1 . Plays a role in endocytosis of frizzled family mbers upon Wnt signaling .
    Molekulargewicht
    65.6 kDa
    UniProt
    Q96CW1
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom
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