Netrin 1 Protein (NTN1) (AA 25-604) (Fc Tag)
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- Target Alle Netrin 1 (NTN1) Proteine anzeigen
- Netrin 1 (NTN1)
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 25-604
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Spezies
- Maus, Human, Ratte
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses Netrin 1 Protein ist gelabelt mit Fc Tag.
- Applikation
- SDS-PAGE (SDS)
- Spezifität
- Binds to human, mouse and rat UNC5B.
- Kreuzreaktivität
- Human, Maus, Ratte (Rattus)
- Produktmerkmale
- Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.
- Reinheit
- >95 % (SDS-PAGE)
- Endotoxin-Niveau
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product NTN1 Protein
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Netrin 1 (NTN1) (AA 495-604) protein (GST tag)
NTN1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Netrin 1 (NTN1) (AA 25-604) protein (His tag)Crystallography grade NTN1 Spezies: Human Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Netrin 1 (NTN1) (AA 25-604) protein (His tag)Crystallography grade NTN1 Spezies: Maus Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Induces pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by inhibiting apoptosis mediated by the receptors DCC or UNC5B (at 150ng /ml). Induces axon outgrowth.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Solid
- Konzentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Haltbarkeit
- 6 months
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- Target
- Netrin 1 (NTN1)
- Andere Bezeichnung
- Netrin-1 (NTN1 Produkte)
- Synonyme
- ntn1-A Protein, Netrin-1 Protein, NTN1 Protein, unc-6 Protein, MGC147073 Protein, NTN1L Protein, AI561871 Protein, BC019633 Protein, netrin-1 Protein, netrin 1 L homeolog Protein, netrin 1 Protein, ntn1.L Protein, NTN1 Protein, ntn1 Protein, Ntn1 Protein
- Hintergrund
- Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.
- Molekulargewicht
- ~90kDa (SDS-PAGE)
- UniProt
- O95631
- Pathways
- Regulation of Cell Size
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