PTPRD
(Protein tyrosine Phosphatase, Receptor Type, D (PTPRD))
Protein-Typ
Recombinant
Proteineigenschaft
AA 21-1265
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses PTPRD Protein ist gelabelt mit His tag.
Sequenz
AA 21-1265
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 140 kDa. The protein migrates as 19 kDa and 120-130 kDa under reducing (R) condition (SDS-PAGE).
Crystallography grade
PTPRD
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, Crys, ELISA
Crystallography grade
PTPRD
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, Crys, ELISA
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Hintergrund
Receptor-type tyrosine-protein phosphatase delta is an enzyme that is encoded by the PTPRD gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRD has been shown to interact with PTPRS and liprin-alpha-1. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported. Mutations in the PTPRD gene are associated with autism, obsessive-compulsive disorder, and breast cancer.