CD276 Protein (CD276) (AA 29-244) (Fc Tag)

Produktnummer ABIN4949156

Produktdetails

Target: CD276

Protein-Typ: Recombinant

Proteineigenschaft: AA 29-244

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CD276 Protein ist gelabelt mit Fc Tag.

Applikation: Functional Studies (Func)

Sequenz: AA 29-244

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.1 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Referenzen

Du, Hirabayashi, Ahn, Kren, Montgomery, Wang, Tiruthani, Mirlekar, Michaud, Greene, Herrera, Xu, Sun, Chen, Ma, Ferrone, Pylayeva-Gupta, Yeh, Liu, Savoldo, Ferrone, Dotti: "Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells." in: Cancer cell, Vol. 35, Issue 2, pp. 221-237.e8, (2019) (PubMed).

Antigendetails

Target: CD276

Andere Bezeichnung: B7-H3 (CD276 Produkte)

Synonyme: sc:d0645 Protein, zgc:158279 Protein, 6030411F23Rik Protein, AU016588 Protein, B7RP-2 Protein, B7h3 Protein, B7H3 Protein, 4Ig-B7-H3 Protein, B7-H3 Protein, CD276 molecule Protein, CD276 molecule S homeolog Protein, CD276 antigen Protein, Cd276 molecule Protein, CD276 Protein, cd276.S Protein, cd276 Protein, Cd276 Protein

Hintergrund: B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

Molekulargewicht: 50.1 kDa

NCBI Accession: NP_598744

Pathways: Cancer Immune Checkpoints