Prorenin Protein

Details zu Produkt Nr. ABIN491434, Anbieter: Anmelden zum Anzeigen
Proteinname
  • renin
  • REN
Spezies
Human
2
2
2
1
Quelle
HEK-293 Cells
4
Protein-Typ
Native
Optionen
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Hersteller Produkt- Nr.
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Produktmerkmale Recombinantly produced in HEK cell culture as untagged native form prorenin and purified by affinity chromatography. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects(2)
Reinigung Chromatographically purified
Reinheit > 95 % by SDS-PAGE
Gen-ID 5972
UniProt Q99665
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Frozen
Konzentration 1.0 mg/mL
Buffer 10 mM Tris, 0.1M NaCl, pH 8.0
Lagerung -80 °C
Bilder des Herstellers
Western Blotting (WB) image for Prorenin protein (ABIN491434) Prorenin protein
Produkt verwendet in: Yisireyili, Saito, Abudureyimu, Adelibieke, Ng, Nishijima, Takeshita, Murohara, Niwa: "Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells." in: PLoS ONE, Vol. 9, Issue 10, pp. e109268, 2014 (PubMed).

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