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Annexin A2 Protein (ANXA2) (AA 2-339) (His tag)

Crystallography grade ANXA2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Produktnummer ABIN3088981
  • Target Alle Annexin A2 (ANXA2) Proteine anzeigen
    Annexin A2 (ANXA2)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 2-339
    Spezies
    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 11
    • 7
    • 6
    • 3
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses Annexin A2 Protein ist gelabelt mit His tag.
    Applikation
    SDS-PAGE (SDS), Western Blotting (WB), ELISA, Crystallization (Crys)
    Sequenz
    MHHHHHHSTV HEILCKLSLE GDHSTPPSAY GSVKAYTNFD AERDALNIET AIKTKGVDEV TIVNILTNRS NAQRQDIAFA YQRRTKKELA SALKSALSGH LETVILGLLK TPAQYDASEL KASMKGLGTD EDSLIEIICS RTNQELQEIN RVYKEMYKTD LEKDIISDTS GDFRKLMVAL AKGRRAEDGS VIDYELIDQD ARDLYDAGVK RKGTDVPKWI SIMTERSVPH LQKVFDRYKS YSPYDMLESI RKEVKGDLEN AFLNLVQCIQ NKPLYFADRL YDSMKGKGTR DKVLIRIMVS RSEVDMLKIR SEFKRKYGKS LYYYIQQDTK GDYQKALLYL CGGDD
    Produktmerkmale
    • Made in Germany - from design to production - by highly experienced protein experts.
    • Human ANXA2 Protein (raised in E. Coli) purified by multi-step, protein-specific process to ensure crystallization grade.
    • State-of-the-art algorithm used for plasmid design (Gene synthesis).

    This made-to-order protein has already been successfully produced. Please let us know if you are interested in purchasing a smaller amount of this protein. We will check our stock and make you a customized quote in case we can provide this protein in a smaller amount.

    When you order this made-to-order protein you will only pay upon receival of the correctly folded protein. With no financial risk on your end you can rest assured that our experienced protein experts will do everything to make sure that you receive the protein you ordered.

    The concentration of our recombinant proteins is measured using the absorbance at 280nm. The protein's absorbance will be measured in several dilutions and is measured against its specific reference buffer.

    The concentration of the protein is calculated using its specific absorption coefficient. We use the Expasy's protparam tool to determine the absorption coefficient of each protein.

    Aufreinigung
    Two step purification of proteins expressed in bacterial culture:
    1. In a first purification step, the protein is purified from the cleared cell lysate using three different His-tag capture materials: high yield, EDTA resistant, or DTT resistant. Eluate fractions are analyzed by SDS-PAGE.
    2. Protein containing fractions of the best purification are subjected to second purification step through size exclusion chromatography. Eluate fractions are analyzed by SDS-PAGE and Western blot.
    Reinheit
    >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Endotoxin has not been removed. Please contact us if you require endotoxin removal.
    Güteklasse
    Crystallography grade
    Top Product
    Discover our top product ANXA2 Protein
  • Applikationshinweise
    In addition to the applications listed above we expect the protein to work for functional studies as well. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
    Kommentare

    In cases in which it is highly likely that the recombinant protein with the default tag will be insoluble our protein lab may suggest a higher molecular weight tag (e.g. GST-tag) instead to increase solubility. We will discuss all possible options with you in detail to assure that you receive your protein of interest.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    20 mM Tris, pH 8.0, 300 mM NaCl, 1 mM EDTA, 2 mM DTT
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C.
    Haltbarkeit
    Unlimited (if stored properly)
  • Target
    Annexin A2 (ANXA2)
    Andere Bezeichnung
    ANXA2 (ANXA2 Produkte)
    Synonyme
    ANX2 Protein, ANX2L4 Protein, CAL1H Protein, LIP2 Protein, LPC2 Protein, LPC2D Protein, P36 Protein, PAP-IV Protein, AW215814 Protein, Cal1h Protein, p36 Protein, anx2 Protein, lip2 Protein, lpc2 Protein, cal1h Protein, lpc2d Protein, pap-i Protein, anx2l4 Protein, MGC76145 Protein, ANXA2 Protein, anxa2 Protein, anxa2-a Protein, anxa2-b Protein, annexin A2 Protein, annexin A2 S homeolog Protein, ANXA2 Protein, Anxa2 Protein, anxa2 Protein, anxa2.S Protein
    Hintergrund
    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). {ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.
    Molekulargewicht
    39.4 kDa Including tag.
    UniProt
    P07355
    Pathways
    S100 Proteine
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