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PDCD1LG2 Protein (AA 20-219) (Fc Tag)

PDCD1LG2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Produktnummer ABIN2870685
  • Target Alle PDCD1LG2 Proteine anzeigen
    PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 20-219
    Spezies
    • 30
    • 12
    • 2
    • 2
    Human
    Quelle
    • 26
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses PDCD1LG2 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 20-219
    Produktmerkmale
    This protein carreis a mouse IgG1 Fc tag at the C-terminus, and has a calculated MW of 48.9 kDa. The predicted N-terminus is Leu 20. The reducing (R) protein migrates as 60-70 kDa in SDS-PAGE due to glycosylation.
    Reinheit
    >95 % as determined by reduced SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product PDCD1LG2 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
  • Tocheva, Lerrer, Mor: "In Vitro Assays to Study PD-1 Biology in Human T Cells." in: Current protocols in immunology, Vol. 130, Issue 1, pp. e103, (2020) (PubMed).

  • Target
    PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
    Andere Bezeichnung
    PD-L2 (PDCD1LG2 Produkte)
    Synonyme
    PDL2 Protein, B7DC Protein, Btdc Protein, CD273 Protein, PD-L2 Protein, PDCD1L2 Protein, bA574F11.2 Protein, B7-DC Protein, F730015O22Rik Protein, programmed cell death 1 ligand 2 Protein, PDCD1LG2 Protein, Pdcd1lg2 Protein
    Hintergrund
    Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
    Molekulargewicht
    48.9 kDa
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