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PD-L1 Protein (AA 19-238) (Fc Tag)

PD-L1 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2870683
  • Target Alle PD-L1 Proteine anzeigen
    PD-L1 (CD274 (PD-L1))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 19-238
    Spezies
    • 42
    • 18
    • 6
    • 5
    • 4
    • 3
    • 1
    Human
    Quelle
    • 47
    • 9
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses PD-L1 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 19-238
    Produktmerkmale
    This protein carries a mouse IgG1 Fc tag at the C-terminus , and has a calculated MW of 51.6 kDa. The predicted N-terminus is Phe 19. The reducing (R) protein migrates as 65-85 kDa in SDS-PAGE due to glycosylation and the non-reducing (NR) protein migrates as 130-170 kDa.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 0.1 EU per μg by the LAL method.
    Top Product
    Discover our top product PD-L1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
  • Tocheva, Lerrer, Mor: "In Vitro Assays to Study PD-1 Biology in Human T Cells." in: Current protocols in immunology, Vol. 130, Issue 1, pp. e103, (2020) (PubMed).

  • Target
    PD-L1 (CD274 (PD-L1))
    Andere Bezeichnung
    PD-L1 (PD-L1 Produkte)
    Synonyme
    B7-H Protein, B7H1 Protein, PD-L1 Protein, PDCD1L1 Protein, PDCD1LG1 Protein, PDL1 Protein, A530045L16Rik Protein, B7h1 Protein, Pdcd1l1 Protein, Pdcd1lg1 Protein, Pdl1 Protein, RGD1566211 Protein, CD274 molecule Protein, CD274 antigen Protein, programmed cell death 1 ligand 2 Protein, CD274 Protein, Cd274 Protein, PDCD1LG2 Protein
    Hintergrund
    Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
    Molekulargewicht
    51.4 kDa
    NCBI Accession
    NP_054862
    Pathways
    Cancer Immune Checkpoints
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