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ITGAV/ITGB6 Protein (AA 31-992) (His tag)

ITGAV/ITGB6 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2870665
  • Target Alle ITGAV/ITGB6 Produkte
    ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 31-992
    Spezies
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 6
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ITGAV/ITGB6 Protein ist gelabelt mit His tag.
    Sequenz
    AA 31-992
    Produktmerkmale
    Human ITGAV & ITGB6 Heterodimer Protein, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 113 kDa (ITGAV) and 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The reducing (R) protein migrates as 145 kDa (ITGAV) and 115 kDa (ITGB6) respectively due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 150 mM NaCl, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
  • Target
    ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
    Andere Bezeichnung
    Integrin alpha V beta 6 (ITGAV/ITGB6 Produkte)
    Hintergrund
    Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency-associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
    Molekulargewicht
    112.9 kDa (ITGAV) & 79.6 kDa (ITGB6)
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