TIRAP Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2733787

Produktdetails

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 3

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TIRAP Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human TIRAP (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Andere Bezeichnung: Tirap (TIRAP Produkte)

Synonyme: mal Protein, wyatt Protein, BACTS1 Protein, Mal Protein, MyD88-2 Protein, AA407980 Protein, C130027E04Rik Protein, Tlr4ap Protein, Wyatt Protein, toll-interleukin 1 receptor (TIR) domain containing adaptor protein Protein, TIR domain containing adaptor protein Protein, toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog Protein, toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Protein, tirap Protein, TIRAP Protein, tirap.L Protein, Tirap Protein

Hintergrund: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants however, not all variants have been fully described.

Molekulargewicht: 23.7 kDa

NCBI Accession: NP_001034750

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades