TYMS Protein (His tag)

Produktnummer ABIN2733655

Produktdetails

Target: TYMS (Thymidylate Synthetase (TYMS))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Insect cells (Sf9)

Aufreinigungstag / Konjugat: Dieses TYMS Protein ist gelabelt mit His tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Thymidylate synthase (TS) (full length, N-term polyhistidine tag) protein expressed in Sf9 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the N-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 50 mM Tris-HCl pH 8.0, 150 mM NaCl, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: TYMS (Thymidylate Synthetase (TYMS))

Andere Bezeichnung: Thymidylate Synthase (Ts) (TYMS Produkte)

Synonyme: FN1 Protein, ECK2823 Protein, JW2795 Protein, ts Protein, Ts Protein, HST422 Protein, TMS Protein, TS Protein, thymidylate synthetase Protein, contains intron in T4 phage Protein, ThyE Protein, thymidylate synthase Protein, thymidylate synthetase L homeolog Protein, TYMS Protein, thyA Protein, td Protein, thyE Protein, DDA3937_RS04960 Protein, tyms.L Protein, XBJ1_RS15770 Protein, EAMY_RS20680 Protein, Tyms Protein

Substanzklasse: Viral Protein

Hintergrund: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Molekulargewicht: 36 kDa

NCBI Accession: NP_001062

Pathways: Mitotic G1-G1/S Phases