PRR5 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2729850

Produktdetails

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PRR5 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human PRR5 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Andere Bezeichnung: Prr5 (PRR5 Produkte)

Synonyme: AU043908 Protein, Arhgap8 Protein, C030017C09Rik Protein, C78947 Protein, Protor-1 Protein, Protor1 Protein, FLJ20185k Protein, PP610 Protein, PROTOR-1 Protein, PROTOR1 Protein, pp610 Protein, protor1 Protein, protor2 Protein, proline rich 5 (renal) Protein, proline rich 5 Protein, proline rich 5 L homeolog Protein, Prr5 Protein, PRR5 Protein, prr5.L Protein

Hintergrund: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Molekulargewicht: 41.4 kDa

NCBI Accession: NP_056181

Pathways: PI3K-Akt Signalweg