PDE1A Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2728480

Produktdetails

Target: PDE1A (Phosphodiesterase 1A (PDE1A))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 1

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PDE1A Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human PDE1A (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: PDE1A (Phosphodiesterase 1A (PDE1A))

Andere Bezeichnung: Pde1a (PDE1A Produkte)

Synonyme: PDE1A Protein, CAM-PDE-1A Protein, HCAM-1 Protein, HCAM1 Protein, HSPDE1A Protein, AI987702 Protein, AW125737 Protein, 3'-RACEclone8phosphodiesterase1A Protein, 3-RACEclone8phosphodiesterase1A Protein, PDE1 Protein, phosphodiesterase 1A Protein, phosphodiesterase 1A, calmodulin-dependent Protein, PDE1A Protein, pde1a Protein, Pde1a Protein

Hintergrund: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1 MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109] Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009].

Molekulargewicht: 62.1 kDa

NCBI Accession: NP_005010

Pathways: Neurotrophin Signalübertragung, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma