NSMCE2 Protein (His tag)

Produktnummer ABIN2727651

Produktdetails

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses NSMCE2 Protein ist gelabelt mit His tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human NSMCE2 (full length, N-term HIS tag) protein expressed in E.coli.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the N-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Andere Bezeichnung: Nsmce2 (NSMCE2 Produkte)

Synonyme: 1110014D18Rik Protein, AI661537 Protein, RGD1305156 Protein, C8orf36 Protein, MMS21 Protein, NSE2 Protein, ZMIZ7 Protein, Non-SMC element 2 Protein, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Protein, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog Protein, Smc5-6 complex non-SMC subunit 2 Protein, Nsmce2 Protein, NSMCE2 Protein, nsmce2.L Protein, nse2 Protein

Hintergrund: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance.

Molekulargewicht: 27.8 kDa

NCBI Accession: NP_775956