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NR0B2 Protein (His tag)

NR0B2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2727536
  • Target Alle NR0B2 Proteine anzeigen
    NR0B2 (Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2))
    Protein-Typ
    Recombinant
    Spezies
    • 3
    • 2
    • 1
    Human
    Quelle
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses NR0B2 Protein ist gelabelt mit His tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human NR0B2 (full length, N-term HIS tag) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product NR0B2 Protein
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the N-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    NR0B2 (Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2))
    Andere Bezeichnung
    Nr0b2 (NR0B2 Produkte)
    Synonyme
    SHP Protein, SHP1 Protein, SHP-1 Protein, Shp1 Protein, Shp Protein, NR0B2-A Protein, Nr0b2 Protein, SHP-A Protein, gb:bc058069 Protein, nuclear receptor subfamily 0 group B member 2 Protein, nuclear receptor subfamily 0, group B, member 2 Protein, nuclear receptor subfamily 0, group B, member 2a Protein, NR0B2 Protein, Nr0b2 Protein, nr0b2a Protein
    Hintergrund
    The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
    Molekulargewicht
    28.1 kDa
    NCBI Accession
    NP_068804
    Pathways
    Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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