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MICA Protein (His tag)

MICA Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2725968
  • Target Alle MICA Proteine anzeigen
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Protein-Typ
    Recombinant
    Spezies
    • 23
    • 1
    Human
    Quelle
    • 12
    • 5
    • 4
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses MICA Protein ist gelabelt mit His tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human MICA protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin-Niveau
    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
    Top Product
    Discover our top product MICA Protein
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Lyophilized from a 0.2 μM filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Andere Bezeichnung
    Mica (MICA Produkte)
    Synonyme
    MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein
    Hintergrund
    This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
    Molekulargewicht
    33.87kD
    NCBI Accession
    NP_000238
    Pathways
    Activation of Innate immune Response, Transition Metal Ion Homeostasis
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