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GDNF Protein (Transcript Variant 1)

GDNF Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
Produktnummer ABIN2721781
  • Target Alle GDNF Proteine anzeigen
    GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    Transcript Variant 1
    Spezies
    • 13
    • 7
    • 3
    • 1
    Human
    Quelle
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Applikation
    Functional Studies (Func), Antibody Production (AbP), Standard (STD), Protein Interaction (PI)
    Spezifität
    Optimal preservation of protein structure, post-translational modifications and functions.
    Produktmerkmale
    • Recombinant human GDNF (transcript variant 1) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Reinheit
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin-Niveau
    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
    Biological Activity Comment
    ED50 was determined by the proliferation of rat C6 cells is > 0.1 ng/ml, corresponding to a specific activity of > 1 x 10^7 units/mg.
    Top Product
    Discover our top product GDNF Protein
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
    Handhabung
    Resuspend the protein in the desired concentration in proper buffer
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
    Andere Bezeichnung
    Gdnf (GDNF Produkte)
    Synonyme
    gdnf Protein, GDNF Protein, AI385739 Protein, gdnfa Protein, hfb1-gdnf Protein, ATF1 Protein, ATF2 Protein, HFB1-GDNF Protein, HSCR3 Protein, glial cell derived neurotrophic factor Protein, glial cell derived neurotrophic factor a Protein, glial cell line derived neurotrophic factor Protein, glial cell derived neurotrophic factor L homeolog Protein, Gdnf Protein, gdnfa Protein, GDNF Protein, gdnf.L Protein
    Hintergrund
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.
    Molekulargewicht
    15 kDa
    NCBI Accession
    NP_000505
    Pathways
    RTK Signalweg, Synaptic Membrane, Tube Formation, Autophagie, Smooth Muscle Cell Migration
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