ESRRG Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2720563

Produktdetails

Target: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ESRRG Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Estrogen-related receptor gamma (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Andere Bezeichnung: Estrogen-Related Receptor gamma (ESRRG Produkte)

Synonyme: ERR3 Protein, ERRgamma Protein, NR3B3 Protein, ESRRG Protein, USH2A Protein, DKFZp459J0417 Protein, err3 Protein, nr3b3 Protein, LOC100219115 Protein, errg Protein, errgamma Protein, esrrg Protein, errb/g Protein, esrrgl Protein, errbeta/gamma Protein, Errg Protein, mKIAA0832 Protein, estrogen related receptor gamma Protein, estrogen-related receptor gamma Protein, estrogen-related receptor gamma a Protein, estrogen-related receptor gamma b Protein, ESRRG Protein, esrrg Protein, Esrrg Protein, esrrga Protein, esrrgb Protein

Hintergrund: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.

Molekulargewicht: 48.4 kDa

NCBI Accession: NP_996317

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway