ERCC8 Protein (His tag)

Produktnummer ABIN2720444

Produktdetails

Target: ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ERCC8 Protein ist gelabelt mit His tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ERCC8 (full length, N-term HIS tag, transcript variant 3) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the N-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))

Andere Bezeichnung: Ercc8 (ERCC8 Produkte)

Synonyme: zgc:103550 Protein, CKN1 Protein, CSA Protein, UVSS2 Protein, Ckn1 Protein, 2410022P04Rik Protein, 2810431L23Rik Protein, 4631412O06Rik Protein, B130065P18Rik Protein, Csa Protein, excision repair cross-complementation group 8 Protein, ERCC excision repair 8, CSA ubiquitin ligase complex subunit Protein, excision repaiross-complementing rodent repair deficiency, complementation group 8 Protein, ercc8 Protein, ERCC8 Protein, Ercc8 Protein

Hintergrund: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 23.2 kDa

NCBI Accession: NP_001007235

Pathways: DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus