ERCC6 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2720440

Produktdetails

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ERCC6 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ERCC6 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Andere Bezeichnung: Ercc6 (ERCC6 Produkte)

Synonyme: ARMD5 Protein, CKN2 Protein, COFS Protein, COFS1 Protein, CSB Protein, RAD26 Protein, UVSS1 Protein, 4732403I04 Protein, C130058G22Rik Protein, ercc6 Protein, Ercc6 Protein, ERCC excision repair 6, chromatin remodeling factor Protein, excision repair cross-complementing rodent repair deficiency, complementation group 6 Protein, excision repair cross-complementation group 6 Protein, DNA excision repair protein ERCC-6 Protein, ERCC6 Protein, Ercc6 Protein, ercc6 Protein, LOC100719487 Protein

Hintergrund: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3&apos splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.

Molekulargewicht: 168.2 kDa

NCBI Accession: NP_000115

Pathways: DNA Reparatur, Chromatin Binding