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DMPK Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

DMPK Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2719535
  • Target Alle DMPK Proteine anzeigen
    DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Transcript Variant 4
    Spezies
    • 7
    • 3
    • 1
    Human
    Quelle
    • 5
    • 3
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses DMPK Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human DMPK (transcript variant 4) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product DMPK Protein
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))
    Andere Bezeichnung
    Dmpk (DMPK Produkte)
    Synonyme
    DMPK Protein, DM Protein, DM1 Protein, DM1PK Protein, DMK Protein, MDPK Protein, MT-PK Protein, Dm15 Protein, DM1 protein kinase Protein, dystrophia myotonica-protein kinase Protein, DMPK Protein, Dmpk Protein
    Hintergrund
    The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3&apos untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
    Molekulargewicht
    69.4 kDa
    NCBI Accession
    NP_001075031
    Pathways
    Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development
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