BCR Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2715211

Produktdetails

Target: BCR (Breakpoint Cluster Region (BCR))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses BCR Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human BCR (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: BCR (Breakpoint Cluster Region (BCR))

Andere Bezeichnung: Bcr (BCR Produkte)

Synonyme: si:dkey-83d9.7 Protein, zK83D9.7 Protein, BCR Protein, ALL Protein, BCR1 Protein, CML Protein, D22S11 Protein, D22S662 Protein, PHL Protein, 5133400C09Rik Protein, AI561783 Protein, AI853148 Protein, mKIAA3017 Protein, breakpoint cluster region Protein, BCR, RhoGEF and GTPase activating protein Protein, bcr Protein, BCR Protein, Bcr Protein

Hintergrund: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 137.5 kDa

NCBI Accession: NP_067585

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling