BCL6 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2715204

Produktdetails

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 1

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses BCL6 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Bcl-6 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Andere Bezeichnung: Bcl-6 (BCL6 Produkte)

Synonyme: bcl5 Protein, laz3 Protein, bcl6a Protein, znf51 Protein, zbtb27 Protein, MGC132260 Protein, Bcl5 Protein, BCL5 Protein, BCL6A Protein, LAZ3 Protein, ZBTB27 Protein, ZNF51 Protein, B-cell CLL/lymphoma 6 L homeolog Protein, B-cell CLL/lymphoma 6 Protein, B cell leukemia/lymphoma 6 Protein, bcl6.L Protein, bcl6 Protein, BCL6 Protein, Bcl6 Protein

Hintergrund: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Molekulargewicht: 78.7 kDa

NCBI Accession: NP_001697

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus