BCAR3 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2715176

Produktdetails

Target: BCAR3 (Breast Cancer Anti-Estrogen Resistance 3 (BCAR3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses BCAR3 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human BCAR3 / SH2D3B protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: BCAR3 (Breast Cancer Anti-Estrogen Resistance 3 (BCAR3))

Andere Bezeichnung: Bcar3,sh2d3b (BCAR3 Produkte)

Synonyme: NSP2 Protein, SH2D3B Protein, AI131758 Protein, AND-34 Protein, BCAR3 Protein, breast cancer anti-estrogen resistance 3 Protein, breast cancer anti-estrogen resistance 3 L homeolog Protein, BCAR3 Protein, Bcar3 Protein, bcar3 Protein, bcar3.L Protein

Hintergrund: Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 92.4 kDa

NCBI Accession: NP_003558