ACER1 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2714568

Produktdetails

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ACER1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Alkaline ceramidase 1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Andere Bezeichnung: Alkaline Ceramidase 1 (ACER1 Produkte)

Synonyme: ASAH3 Protein, asah3 Protein, zgc:110285 Protein, ALKCDase1 Protein, 2310024P18Rik Protein, AI662009 Protein, Alkcdase1 Protein, Asah3 Protein, Cer1 Protein, alkaline ceramidase 1 Protein, ACER1 Protein, acer1 Protein, Acer1 Protein

Hintergrund: Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081] Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010].

Molekulargewicht: 30.9 kDa

NCBI Accession: NP_597999