CYP2D6 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2712768

Produktdetails

Target: CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CYP2D6 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human CYP2D6 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))

Andere Bezeichnung: Cyp2d6 (CYP2D6 Produkte)

Synonyme: CPD6 Protein, CYP2D Protein, CYP2D7AP Protein, CYP2D7BP Protein, CYP2D7P2 Protein, CYP2D8P2 Protein, CYP2DL1 Protein, CYPIID6 Protein, P450-DB1 Protein, P450C2D Protein, P450DB1 Protein, CYP2D42 Protein, MGC64445 Protein, cyp2d2 Protein, cyp2d6-a Protein, CYP2D6 Protein, cytochrome P450 family 2 subfamily D member 6 Protein, cytochrome P450, family 2, subfamily D, polypeptide 6 Protein, cytochrome 2D6 Protein, cytochrome P450 family 2 subfamily D member 6 S homeolog Protein, cytochrome P450 2D6 Protein, cytochrome P450 2D6-like Protein, CYP2D6 Protein, cyp2d6-b Protein, cyp2d6.S Protein, cyp2d6 Protein, LOC100988273 Protein

Hintergrund: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25 % of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme&aposs substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 49.8 kDa

NCBI Accession: NP_001020332