CREBL2 Protein (His tag)

Produktnummer ABIN2712551

Produktdetails

Target: CREBL2 (CAMP Responsive Element Binding Protein-Like 2 (CREBL2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CREBL2 Protein ist gelabelt mit His tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human CREBL2 (full length, N-term HIS tag) protein expressed in E.coli.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the N-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: CREBL2 (CAMP Responsive Element Binding Protein-Like 2 (CREBL2))

Andere Bezeichnung: Crebl2 (CREBL2 Produkte)

Synonyme: CREBL2 Protein, AI046348 Protein, B230205M03 Protein, cAMP responsive element binding protein like 2 Protein, cAMP responsive element binding protein-like 2 Protein, CREBL2 Protein, LOC100223083 Protein, Crebl2 Protein

Hintergrund: CAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41 % identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.

Molekulargewicht: 13.6 kDa

NCBI Accession: NP_001301

Pathways: Positive Regulation of fat Cell Differentiation