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KDM4C Protein (DYKDDDDK Tag)

KDM4C Spezies: Human Wirt: Baculovirus Recombinant EAA, ScA
Produktnummer ABIN2669706
  • Target Alle KDM4C Proteine anzeigen
    KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))
    Protein-Typ
    Recombinant
    Spezies
    • 5
    • 1
    • 1
    Human
    Quelle
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Baculovirus
    Aufreinigungstag / Konjugat
    Dieses KDM4C Protein ist gelabelt mit DYKDDDDK Tag.
    Applikation
    Enzyme Activity Assay (EAA), Screening Assay (ScA)
    Produktmerkmale
    Recombinant JMJD2C / KDM4C (accession number NP_055876.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with a calculated molecular weight of 124.1 kDa.
    Top Product
    Discover our top product KDM4C Protein
  • Applikationshinweise
    Recombinant JMJD2C / KDM4C is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. Specific Activity: H3K9me3 and H3K36me3 demethylase. Catalytic Activity: >100 turnovers/ enzyme molecule Histone Demethylase Assay Conditions: 50 mM HEPES pH 7.5, 0.02 % Triton X100, 100 μM 2OG, 100 μM Ascorbate, 50 μM (NH4)2Fe(SO4)2•6H2O, 1 mM TCEP, 60 nM Recombinant JMJD2C / KDM4C protein, and 3.3 μM H3K9me3 (aa 1-21) peptide at 2 hours at room temperature. MALDI-TOF was used for detection.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Handhabung
    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
  • Target
    KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))
    Andere Bezeichnung
    JMJD2C / KDM4C (KDM4C Produkte)
    Synonyme
    JMJD2C Protein, GASC1 Protein, JHDM3C Protein, TDRD14C Protein, bA146B14.1 Protein, 2410141F18Rik Protein, AA517467 Protein, Gasc1 Protein, Jmjd2c Protein, lysine demethylase 4C Protein, jumonji domain containing 2c Protein, lysine (K)-specific demethylase 4C Protein, KDM4C Protein, Jmjd2c Protein, kdm4c Protein, Kdm4c Protein
    Hintergrund
    KDM4C (lysine (K)-specific demethylase 4C), also known as JMJD2C (Jumonji Domain Containing 2C) is a nuclear protein that functions as a trimethylation-specific histone demethylase that preferentially demethylates trimethylated lysine 9 (K9me3) and lysine 36 (K36me3) residues of histone H3, converting these trimethylated histone residues to dimethylated form. KDM4C has no activity for mono- and dimethylated H3K9 and H3K36. Chromosomal aberrations and overexpression of KDM4C are associated with esophageal squamous cell carcinoma. KDM4C regulates colonosphere formation in colorectal cancers by mediating the crosstalk between Wnt and Notch signaling pathways.
    Molekulargewicht
    124.1 kDa
    Pathways
    Nuclear Hormone Receptor Binding, Warburg Effekt
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