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BRD4 Protein (AA 333-460) (His tag,DYKDDDDK Tag)

BRD4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Bind, ScA
Produktnummer ABIN2669694
  • Target Alle BRD4 Proteine anzeigen
    BRD4 (Bromodomain Containing 4 (BRD4))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 333-460
    Spezies
    • 5
    • 1
    Human
    Quelle
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses BRD4 Protein ist gelabelt mit His tag,DYKDDDDK Tag.
    Applikation
    Binding Studies (Bind), Screening Assay (ScA)
    Produktmerkmale
    The peptide corresponding to amino acids 333-460 that contains the bromodomain sequences of BRD4 (accession number NP_490597.1) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 20.9 kDa.
    Top Product
    Discover our top product BRD4 Protein
  • Applikationshinweise
    Recombinant BRD4 (333-460) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Handhabung
    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
  • Target
    BRD4 (Bromodomain Containing 4 (BRD4))
    Andere Bezeichnung
    BRD4 (BRD4 Produkte)
    Synonyme
    brd4-b Protein, BRD4 Protein, fb18g03 Protein, wu:fb18g03 Protein, CAP Protein, HUNK1 Protein, HUNKI Protein, MCAP Protein, Brd5 Protein, WI-11513 Protein, bromodomain containing 4 L homeolog Protein, bromodomain containing 4 Protein, bromodomain-containing protein 4 Protein, brd4.L Protein, BRD4 Protein, brd4 Protein, LOC100409351 Protein, Brd4 Protein
    Hintergrund
    Bromodomain-containing protein 4 (BRD4) belongs to the BET subclass of proteins, which are characterized by two N-terminal bromodomains and one ET (Extra Terminal) domain. BRDs associate with chromatin through their bromodomains that recognize acetylated histone lysine residues. Bromodomains function as 'readers' of these epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. The ET domain functions as a protein binding motif and exerts atypical serine-kinase activity. The BET family consists of at least four members in mouse and human, BRD2 (also referred to as FSRG1, RING3), BRD3 (FSRG2, ORFX), BRD4 (FSRG4, MCAP/HUNK1), and BRDT (FSRG3, BRD6). BRD proteins are related to the female Sterile Homeotic protein gene in Drosophila, a gene required maternally for proper expression of other homeotic genes, such as Ubx, which is involved in pattern formation. BRD4 has been identified recently as a therapeutic target in many cancers, including acute myeloid leukemia, multiple myeloma, Burkitt's lymphoma, NUT midline carcinoma, colon cancer, and breast cancer. BRD4 regulates the transcription of oncogenes, HIV, and human papilloma virus (HPV). It has been shown to bind and phosphorylate RNA pol II, which implicates its involvement in the regulation of eukaryotic transcription.
    Molekulargewicht
    20.9 kDa
    Pathways
    Chromatin Binding, SARS-CoV-2 Protein Interaktom
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