c-FOS Protein (full length) (His tag)

Produktnummer ABIN2669410

Produktdetails

Target: c-FOS (c-Fos) (c-Fos)

Protein-Typ: Recombinant

Proteineigenschaft: full length

Spezies: Human

Quelle: Baculovirus

Aufreinigungstag / Konjugat: Dieses c-FOS Protein ist gelabelt mit His tag.

Applikation: Protein Interaction (PI)

Produktmerkmale: Recombinant c-Fos was expressed from full length (accession number NM 003131) with an amino terminal polyhistidine tag in a baculovirus system and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.

Aufreinigung: Purified by an affinity column in combination with FPLC chromatography.

Reinheit: The purified recombinant protein is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.

Anwendungsinformationen

Applikationshinweise: Recombinant c-Fos is suitable for DNA and protein-protein interaction assays. 100 ng is sufficient for DNA-protein and protein-protein interaction studies. The molecular weight of the protein is ~50 kDa. The standard curve for TransAM® AP-1 c-Fos was generated using the range of 40-2.5 ng of protein. NOTE: The presence of Poly [d(I-C)] in buffers may affect protein functionality and should be avoided.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Antigendetails

Target: c-FOS (c-Fos) (c-Fos)

Andere Bezeichnung: C-Fos (c-Fos Produkte)

Synonyme: AP-1 Protein, C-FOS Protein, p55 Protein, c-fos Protein, D12Rfj1 Protein, cFos Protein, cFOS Protein, fos Protein, Fos proto-oncogene, AP-1 transcription factor subunit Protein, FBJ osteosarcoma oncogene Protein, proto-oncogene c-Fos-like Protein, FOS Protein, Fos Protein, LOC101078177 Protein

Hintergrund: C-Fos is one of the proteins that form the heteromeric AP-1 transcription factor complex. AP-1 proteins play a role in the expression of many genes involved in the regulation of cellular processes such as differentiation, proliferation and apoptosis. The transcription factor AP-1 is composed of a mixture of heterodimeric protein complexes derived from the Fos and Jun families, including c-Fos, FosB, Fra-1, c-Jun, JunB and JunD. c-Fos is a nuclear phosphoprotein that forms a tight but non-covalently linked complex with the Jun/AP-1 transcription factor. In the heterodimer, Fos and Jun/AP-1 basic regions each seem to interact with symmetrical DNA half sites. Upon TGF-β activation, c-Fos forms a multimeric SMAD3/SMAD4/Jun/Fos complex at the AP-1/SMAD-binding site to regulate TGF-β-mediated signaling. c-Fos has a critical function in regulating bone morphogenesis.

Pathways: S100 Proteine