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IL1F9 Protein (AA 18-169)

IL1F9 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis. WB, IF Active
Produktnummer ABIN2667525
  • Target Alle IL1F9 Proteine anzeigen
    IL1F9 (Interleukin 1 Family Member 9 (IL1F9))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 18-169
    Spezies
    • 12
    • 5
    • 1
    Human
    Quelle
    • 16
    • 1
    • 1
    Escherichia coli (E. coli)
    Applikation
    Western Blotting (WB), Immunofluorescence (IF)
    Reinheit
    >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
    Endotoxin-Niveau

    Less than 0.1 ng per μg of protein.

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    Discover our top product IL1F9 Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Biological activity: Measured by its ability to induce IL-8 production by human PBMCs.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
    Buffer
    Lyophilized, carrier-free.
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Unopened vial can be stored at -20°C or -70°C.
  • Target
    IL1F9 (Interleukin 1 Family Member 9 (IL1F9))
    Andere Bezeichnung
    IL-36 gamma (IL1F9 Produkte)
    Synonyme
    IL-1F9 Protein, IL-1H1 Protein, IL-1RP2 Protein, IL1E Protein, IL1F9 Protein, IL1H1 Protein, IL1RP2 Protein, Il36g Protein, Il1f9 Protein, RGD1563019 Protein, IL36G Protein, interleukin 36 gamma Protein, interleukin 1 family, member 9 Protein, interleukin 36, gamma Protein, interleukin-36 gamma Protein, IL36G Protein, Il1f9 Protein, Il36g Protein, LOC100065031 Protein
    Hintergrund
    The IL-1 family is a group of cytokines comprised of 11 membranes, including recently renamed IL-36 cytokines, IL-36 α, β and γ (previously known as IL-1F6, IL-1F8 and IL-1F9). IL-36γ signals through the IL-1 receptor family members IL-1Rrp2 and IL-1RAcP and can activate downstream MAP kinases and transfection factor NF-kB. IL-36γ is synthesized without signal peptide and the secretion pathway is unclear. It has been shown that, like other IL-36 cytokines, N-terminal processing of IL-36γ can significantly increase its biological activity. The possible processing enzymes are currently unknown. IL-36γ also plays a significant role in immune response. Low level of IL-36 receptor IL-1Rrp can be detected on bone marrow-derived dendritic cells and CD4+ T cells. IL-36γ treatment can upgulate CD80, CD86 and MHC Class II, and proinflammatory cytokine producton in dendritic cells. IL-36γ has also been implicated in airway hyperesponsiveness. Intranasal administration of recombinant IL-36γ in mice leads to epithelial cell hypertrophy, cellular infiltration, and mucus production. IL-36γ expression in the lungs of mice can be upregulated by allergic inflammation.
    Molekulargewicht
    The 152 amino acid recombinant protein has a predicted molecular mass of approximately 17 kDa. The predicted N-terminal amino acid is Ser.
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