Interleukin 6 (IL6) (Active) protein (Biotin)

Details zu Produkt Nr. ABIN2566711, Anbieter: Anmelden zum Anzeigen
Proteinname
  • BSF2
  • HGF
  • HSF
  • IFNB2
  • IL-6
  • Il-6
  • ILg6
  • Ifnb2
  • il6
  • Fsp
  • Gro1
  • KC
  • Mgsa
  • N51
  • Scyb1
  • gro
  • CHIL-6
  • interleukin 6
  • interleukin-6
  • chemokine (C-X-C motif) ligand 1
  • IL6
  • Il6
  • il-6
  • Cxcl1
  • IL-6
Spezies
Human
84
46
29
5
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Quelle
HEK-293 Cells
139
26
13
7
3
2
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses Interleukin 6 Protein ist gelabelt mit Biotin.
Applikation
ELISA, Western Blotting (WB)
Optionen
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Hersteller Produkt- Nr.
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Produktmerkmale

Measured by its binding ability in a functional ELISA. Immobilized Human IL6R /CD126 Protein at 5 μg/mL (100 μL/well),can bind Biotinylated rh IL6 Protein. The EC50 is typically 0. 06-0. 6 μg/mL.

Reinheit >95 % as determined by SDS-PAGE.
Hintergrund Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases. The primary amine of rh IL6 was labeled by biotin without decreasing its bioactivity, and has been used successfully for easy detection in ELISA, dot blot or Western blot, immunohistochemistry applications using streptavidin or avidin-conjugated probes. Biotin and other reactive related chemicals have been removed thoroughly by desalting after reaction termination.
Molekulargewicht 20.8 kDa
Gen-ID 3569
NCBI Accession NP_000591
UniProt P05231
Pathways Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagie, Cell RedoxHomeostasis
Applikationshinweise This recombinant protein can be used for WB, ELISA. For research use only.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer PBS, pH 7.4
Lagerung -80 °C,-20 °C
Informationen zur Lagerung Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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