RCAN2 Protein (AA 2-197, Isoform 2) (His tag)

Produktnummer ABIN2469007

Produktdetails

Target: RCAN2 (Regulator of Calcineurin 2 (RCAN2))

Protein-Typ: Recombinant

Proteineigenschaft: Isoform 2, AA 2-197

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses RCAN2 Protein ist gelabelt mit His tag.

Applikation: ELISA, Western Blotting (WB), Mass Spectrometry (MS), Neutralization (Neut)

Reinheit: ~95 %

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 mM sodium phosphate, 10 mM Tris, 500 mM NaCl, 25 mM imidazole, 2 mM MgCl2, 10 % gycerol

Handhabung: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Lagerung: -80 °C

Informationen zur Lagerung: Store in working aliquots at -70 °C.

Antigendetails

Target: RCAN2 (Regulator of Calcineurin 2 (RCAN2))

Andere Bezeichnung: RCAN2 (RCAN2 Produkte)

Synonyme: DSCR1L1 Protein, si:ch211-124g24.1 Protein, zgc:85746 Protein, RCAN2 Protein, DKFZp459H071 Protein, rcan2 Protein, CSP2 Protein, MCIP2 Protein, RCN2 Protein, ZAKI-4 Protein, ZAKI4 Protein, Csp2 Protein, Dscr1l1 Protein, Dcip2 Protein, Zaki-4 Protein, regulator of calcineurin 2 Protein, rcan2 Protein, RCAN2 Protein, Rcan2 Protein

Hintergrund: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle (1,2). Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin s activity (3). Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3 (3). RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome (4).

Molekulargewicht: 26 kDa (Calculated)

Gen-ID: 53901

OMIM: 38328420

UniProt: Q9JHG2