Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 24-297) (Active) protein (Strep Tag,Biotin,His tag)

Details zu Produkt Nr. ABIN2444126
Proteinname
  • FCRN
  • alpha-chain
  • FcRn
  • Fc fragment of IgG receptor and transporter
  • Fc receptor, IgG, alpha chain transporter
  • FCGRT
  • Fcgrt
Proteineigenschaft
AA 24-297
6
4
3
2
2
1
1
1
1
1
1
1
Spezies
Human
10
6
3
3
2
2
Quelle
HEK-293 Cells
14
4
2
1
1
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses FCGRT Protein ist gelabelt mit Strep Tag,Biotin,His tag.
Optionen
Marke MABSol®,UltraLys
Spezifität The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
Produktmerkmale The subunit FCGRT carries a polyhistidine tag at the C-terminus. The subunit B2M carries a Strep II tag at the C-terminus. The protein has a calculated MW of 31.2 kDa (FCGRT), 13.1 kDa (B2M) . The protein migrates as 33 kDa (FCGRT), 13 kDa (B2M) respectively on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Reinheit >95 % as determined by SDS-PAGE.
Endotoxin-Niveau Less than 1.0 EU per μg by the LAL method.
Güteklasse Ultra Sensitive
Proteinname
Hintergrund FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Molekulargewicht 31.2 kDa (FCGRT), 13.1 kDa (B2M)
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Kommentare

A chemically labeled biotinylated protein with ultra sensitivity.
The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
Bilder des Herstellers
SDS-PAGE (SDS) image for Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 24-297) (Active) protein (Strep Tag,Biotin,His tag) (ABIN2444126) Biotinylated Human FcRn / FCGRT & B2M on SDS-PAGE under reducing (R) condition. The g...
Binding Studies (Bind) image for Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 24-297) (Active) protein (Strep Tag,Biotin,His tag) (ABIN2444126) Immobilized Yervoy Ipilimumab (Human IgG1) at 10 μg/mL (100 μL/well) can bind Biotiny...
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