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Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 27-756) (Active) protein (His tag) Protein

FLT1 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed (1 reference)
Produktnummer ABIN2181915
$330.00
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Lieferung in 5 Werktagen
  • Target Alle FLT1 Proteine anzeigen
    FLT1
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 27-756
    Spezies
    • 21
    • 3
    • 3
    • 3
    • 1
    Human
    Quelle
    • 11
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses FLT1 Protein ist gelabelt mit His tag.
    Sequenz
    AA 27-756
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 83 kDa. The protein migrates as 115-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Keys, Wetter, Hang, Rutschmann, Russo, Mally, Steffen, Zuppiger, Müller, Schneider, Faridmoayer, Lin, Aebi: "A biosynthetic route for polysialylating proteins in Escherichia coli." in: Metabolic engineering, Vol. 44, pp. 293-301, (2018) (PubMed).

  • Target
    FLT1
    Andere Bezeichnung
    VEGF R1 (FLT1 Produkte)
    Synonyme
    FLT, FLT-1, VEGFR-1, VEGFR1, FLT1, flt1b, sFlt1, AI323757, Flt-1, fms related tyrosine kinase 1, FMS-related tyrosine kinase 1, vascular endothelial growth factor receptor 1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), FMS-like tyrosine kinase 1, vascular endothelial growth factor receptor-1, FLT1, Flt1, CpipJ_CPIJ012087, flt1, FLT-1
    Hintergrund
    Vascular endothelial growth factor receptor 1 (VEGFR1) is also known as Fms-like tyrosine kinase 1 (FLT-1), Tyrosine-protein kinase receptor FLT, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR1 is detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues and specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. VEGFR1 can promote endothelial cell proliferation, survival and angiogenesis in adulthood.
    Molekulargewicht
    83.3 kDa
    NCBI Accession
    NP_002010
    Pathways
    RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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