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Transferrin (TF) (AA 20-698) (Active) protein (His tag) Protein

TF Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181871
$341.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle Transferrin (TF) Proteine anzeigen
    Transferrin (TF)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 20-698
    Spezies
    • 16
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Quelle
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Transferrin Protein ist gelabelt mit His tag.
    Sequenz
    AA 20-698
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76 kDa. The protein migrates as 74 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • Target
    Transferrin (TF)
    Andere Bezeichnung
    Transferrin (TF Produkte)
    Synonyme
    ltf, pro1557, pro2086, mgc107777, LOC692564, TF, LOC100144362, tf, LTF, TFEW, conalbumin, tf-b, MGC64306, PRO1557, PRO2086, TFQTL1, AI266983, Cd176, HP, Tf, Tfn, hpx, Trf, cb285, gavi, id:ibd3238, id:ibd3525, sb:cb285, wu:fb57g06, wu:fb62h02, wu:fb63h10, wu:fb64h10, zgc:112154, 143958_at, CG6186, Dmel\\CG6186, TSF1, anon-EST:Posey265, tsf1, Pro-TRH, IL-5, STF I, TRF1, sTF1, sTf, tf1, transferrin, serotransferrin, transferrin (ovotransferrin), transferrin L homeolog, melanotransferrin, transferrin-a, Transferrin 1, thyrotropin releasing hormone, interleukin 5, TF, LOC477072, tf, Tf, LOC100144362, tf.L, LOC5575625, Trf, tfa, Tsf1, TRH, IL5, LOC101085148, LOC100726872, trf
    Hintergrund
    Transferrin is also known as Serotransferrin, Beta-1 metal-binding globulin, TF, and is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. Although iron bound to transferrin is less than 0.1 % (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). The affinity of transferrin for Fe(III) is extremely high (1023 M-1 at pH 7.4) but decreases progressively with decreasing pH below neutrality.When not bound to iron, it is known as "apo-transferrin"". In humans, transferrin consists of a polypeptide chain containing 679 amino acids. It is a complex composed of alpha helices and beta sheets to form two domains (the first situated in the N-terminus and the second in the C-terminus). The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site. The liver is the main source of manufacturing transferrin, but other sources such as the brain also produce this molecule . Transferrin is also associated with the innate immune system. Transferrin is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacteria survival in a process called iron withholding. The level of transferrin decreases in inflammation. The metal binding properties of transferrin have a great influence on the biochemistry of plutonium in humans. Transferrin has a bacteriocidal effect on bacteria, in that it makes Fe3+ unavailable to the bacteria.Carbohydrate deficient transferrin increases in the blood with heavy ethanol consumption and can be monitored via laboratory testing.
    Molekulargewicht
    76.0 kDa
    Pathways
    Transition Metal Ion Homeostasis
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