R-Spondin 3 Protein (RSPO3) (AA 22-146) (His tag)

Produktnummer ABIN2181682

Produktdetails

Target: R-Spondin 3 (RSPO3)

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-146

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses R-Spondin 3 Protein ist gelabelt mit His tag.

Sequenz: AA 22-146

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.3 kDa. The protein migrates as 18 kDa and 24 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

Reinheit: >90 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Antigendetails

Target: R-Spondin 3 (RSPO3)

Andere Bezeichnung: R-Spondin 3 (RSPO3 Produkte)

Synonyme: pwtsr Protein, thsd2 Protein, cristin1 Protein, CRISTIN1 Protein, PWTSR Protein, THSD2 Protein, RGD1563246 Protein, 2810459H04Rik Protein, AW742308 Protein, Cristin1 Protein, Thsd2 Protein, R-spondin 3 Protein, rspo3 Protein, RSPO3 Protein, Rspo3 Protein

Hintergrund: R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.

Molekulargewicht: 15.9 kDa