JAG1 Protein (AA 34-1046) (His tag)

Produktnummer ABIN2181410

Produktdetails

Target: JAG1 (Jagged 1 (JAG1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 34-1046

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses JAG1 Protein ist gelabelt mit His tag.

Sequenz: AA 34-1046

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 112.3 kDa. The protein migrates as 160-180 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >90 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C.

Antigendetails

Target: JAG1 (Jagged 1 (JAG1))

Andere Bezeichnung: Jagged 1 (JAG1 Produkte)

Synonyme: AGS Protein, AHD Protein, AWS Protein, CD339 Protein, HJ1 Protein, JAGL1 Protein, ABE2 Protein, Gsfabe2 Protein, Htu Protein, Ozz Protein, Ser-1 Protein, JAG1 Protein, jag3 Protein, cb243 Protein, jag1 Protein, sb:cb243 Protein, serrateC Protein, jagged1 Protein, serrate Protein, serrate-1 Protein, x-serrate-1 Protein, jagged 1 Protein, jagged 1b Protein, jagged 1a Protein, jagged 1 L homeolog Protein, JAG1 Protein, Jag1 Protein, jag1 Protein, jag1b Protein, jag1a Protein, jag1.L Protein

Hintergrund: Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).

Molekulargewicht: 112.3 kDa

NCBI Accession: NP_000205

Pathways: Notch Signalweg, Stem Cell Maintenance