FCGR3A Protein (AA 17-208) (His tag)
(2 Referenzen)-
- Target Alle FCGR3A Proteine anzeigen
- FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 17-208
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses FCGR3A Protein ist gelabelt mit His tag.
- Marke
- MABSol®
- Sequenz
- AA 17-208
- Produktmerkmale
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.7 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Reinheit
- >95 % as determined by SDS-PAGE.
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product FCGR3A Protein
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Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208) protein (His-Avi Tag)
FCGR3A Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) protein (His-Avi Tag,Biotin)FCGR3A Spezies: Human Wirt: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-254) protein (GST tag)FCGR3A Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) protein (His tag)FCGR3A Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) protein (His tag)FCGR3A Spezies: Cynomolgus Wirt: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (Active) protein (His tag,AVI tag)FCGR3A Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (Active) protein (His tag)FCGR3A Spezies: Human Wirt: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. Active
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (Active) protein (His tag)FCGR3A Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (Active) protein (Biotin,His-Avi Tag)FCGR3A Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208) protein (His tag)Crystallography grade FCGR3A Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
: "Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies." in: Cancer biology & therapy, pp. 1-9, (2019) (PubMed).
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: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
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- Target
- FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
- Andere Bezeichnung
- Fc gamma RIIIA / CD16a (FCGR3A Produkte)
- Synonyme
- CD16 Protein, CD16A Protein, FCG3 Protein, FCGR3 Protein, FCGRIII Protein, FCR-10 Protein, FCRIII Protein, FCRIIIA Protein, IGFR3 Protein, Fcgr4 Protein, Fc fragment of IgG receptor IIIa Protein, FCGR3A Protein, Fcgr3a Protein
- Hintergrund
- CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
- Molekulargewicht
- 23.7 kDa
- NCBI Accession
- NP_000560
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